Protein Structure Determination
The protein structure determination capability provides insights into the molecular structure of proteins, and how proteins form interactions with other molecules, for example, protein-protein, protein-DNA, protein-drug and protein-lipid complexes.
This capability uses X-ray crystallography and biophysical characterisation tools, such as circular dichroism spectroscopy, to visualise the structures.
There is a broad range of applications that this capability can assist you with including:
- three-dimensional structure determination of biological macromolecules at near atomic resolution
- understanding structure-function relationship of biological molecules
- atomic details of biological molecule-ligand interactions
- structure-based drug design.
We provide advice on experimental design and methodology.
Jasco J-1100 Circular Dichroism Spectrometer
Used to determine the secondary structure of proteins and peptides in aqueous solution.
Agilent Technologies Supernova X-ray Diffractometer
Provides an in-house x-ray source for measuring diffraction of protein crystals for the subsequent determination of the three-dimensional structure.
Australian Synchrotron
We have access to the macromolecular & micro crystallography beamline which is an X-ray source used to rapidly create diffraction patterns of protein crystals for the subsequent determination of the three-dimensional structure.
Gryphon Crystallisation Robot and Memmert Crystallisation Incubators
Used to grow protein crystals for subsequent structural analysis
Access
Contact us to discuss your research applications:
- research Contracts for bespoke projects
- academic collaboration.
Contact us
For more information and to discuss your requirements, please contact A/Prof. Begona Heras:
- T: (+61 3) 9479 3185
- E: A/Prof. Begona Heras
- W: Scholars profile.